Neurotransmitters and other chemical signalling agents
| GLUTAMATE (and ASPARTATE) | |||
|---|---|---|---|
| Precursors: | None | ||
| Synthesising enzymes: | None | ||
| Metabolising enzymes: | Glutamate transaminase (uptake is more important) | ||
| Metabolite: | Glutamine | ||
| Receptor subtypes | Agonists | Antagonists | Second messenger |
| NMDA (subtypes MB) |
NMDA, AP5, CPP |
CGP37849 (MK801 is a channel blocker, PCP is non-competitive) |
(+ve)g(cation) |
| AMPA (subtypes MB) |
AMPA, quisqualate | NBQX, CNQX DNQX |
(+ve)g(cation) |
| Kainate (subtypes MB) |
Kainate, domoate | NBQX, CNQX DNQX |
(+ve)g(cation) |
| Metabotropic (subtypes MB) |
1S,3R-ACPD, ibotenate |
None | PI |
NB: (+ve) indicates increase; (-ve) indicates decrease.
Reviews
Erdo, S.L. (1992) Trends Pharmacol. Sci. 12, 426-429.
Gasic, G.P. and Hollman, M. (1992) Ann. Rev. Physiol. 54, 507-536.
Nakanishi, S. (1992) Science 258, 597-603.
Schoepp, D.D. and Conn, P.J. (1993) Trends Pharmacol. Sci. 14, 13-20
Sommer, B. and Seeberg, P.H. (1992) Trends Pharmacol. Sci. 13, 291-296.
Glycine
Enkephalin
and Dynorphin
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