Search Glaxo Wellcome

Glaxo Wellcome
Pharmacology Guide

Neurotransmitters and other chemical signalling agents

ENKEPHALIN (met- and leu-) and DYNORPHIN
Precursors: Proenkephalin and prodynorphin  
Synthesising enzymes: Peptidases
Metabolising enzymes: Enkephalinase (EC 24:11) and other peptidases
Metabolite: Peptide fragments
Receptor subtypes Agonists Antagonists Second messenger
µ-opoid DAGOL (DAMGO) Naloxone (-ve)cAMP, (+ve)gK+
delta-opoid DPDPE Naltrindol (-ve)cAMP, (+ve)gK+
kappa-opoid U69593, CI 977,
dynorphin
Norbinaltorphimine (-ve)gCa2+

Reviews
Kosterlitz, H.W. and Paterson, S.J. (1985) Phil. Trans. Roy. Soc. Lond. 308, 291-297. Millan, M.J. (1990) Trends Pharmacol. Sci. 11, 70-73.


Forward  Glutamate and Aspartate
Back  Endothelin
Return  Table of Contents


Our World Bookmark News Healthcare Download Science Contact Home page