Neurotransmitters and other chemical signalling agents
| ANGIOTENSIN II (AT II) | |||
|---|---|---|---|
| Precursors: | Angiotensin I | ||
| Synthesising enzymes: | Angiotensin converting enzyme (ACE) | ||
| Metabolising enzymes: | Aminopeptidase | ||
| Metabolite: | Angiotensin III | ||
| Receptor subtypes | Agonists | Antagonists | Second messenger |
| AT1 | Angiotensin II,III | Losartan (DuP753), GR 117289 |
PI, (-ve)cAMP |
| AT2 | Angiotensin II,III | PD 123177, PD 123319, CGP42112 |
(-ve)cGMP |
NB: (+ve) indicates increase; (-ve) indicates decrease.
Reviews
Peach, M.J. and Dostal, D.E. (1990) J. Cardiovasc. Pharmacol. 16 (suppl. 4),
525-530.
Steckelings, U.M., Bottari, S.P. and Unger, T. (1992) Trends Pharmacol. Sci.
13, 365-368.
ATP
Gamma-Aminobutyric
acid
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