Neurotransmitters and other chemical signalling agents
| g-AMINOBUTYRIC ACID (GABA) | |||
|---|---|---|---|
| Precursors: | Glutamate | ||
| Synthesising enzymes: | Glutamic acid decarboxylase (GAD) | ||
| Metabolising enzymes: | GABA transaminase | ||
| Metabolite: | Succinic semialdehyde | ||
| Receptor subtypes | Agonists | Antagonists | Second messenger |
| GABAA | Muscimol, THIP, isoguvacin |
Bicuculline, picrotoxin |
(+ve)gCl |
| GABAB | Baclofen, CGP 97541 |
2-OH-Saclofen, CGP 35348 |
(-ve)gK+, (-ve)gCa2+, (-ve)cAMP |
| Benzodiazepine site on GABAA receptor |
Diazepam (DMCM is an inverse agonist) |
Flumazenil | Enhances (+ve)gCl- by GABA |
NB: (+ve) indicates increase; (-ve) indicates decrease.
Reviews
Tallman, J.F. and Gallagher, D.W. (1985) Ann. Rev. Neurosci. 8, 21-44.
Bowery, N. (1989) Trends Pharmacol. Sci. 10, 401-407.
Angiotensin II
Adenosine
Table of Contents
 |
 |
 |
 |
 |
 |
 |
 |