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Glaxo Wellcome
Pharmacology Guide

In vitro pharmacology: common isolated tissue preparations

GIF version of table

Preparation Receptors commonly studied Bathing Solution *
Frog rectus abdominis ACh (nicotinic, muscle-type) Frog Ringer
Guinea-pig ascending colon 5HT(4) Krebs'
Guinea-pig ileum ACh (muscarinic M(3)), histamine H(1) & H(3),
neurokinin NK(1),
bradykinin B(2), 5HT(3),
CCK(A), CCK(B), Angiotensin AT(2)
Krebs' or Tyrode
Guinea-pig ileum
(fd smd.)
mu- and kappa-opioid,
alpha(2)-adrenoceptors
Krebs' or Tyrode
Guinea-pig vas deferens EP(3) Krebs'
Mouse vas deferens (fd smd.) mu- kappa- and delta-opioid,
dopamine D(2)
Krebs' (minus Mg(2+))
Rabbit jejunum alpha(2)-adrenoceptors Tyrode
Rabbit heart
Langendorff
beta(1)-adrenoceptors Ringer-Locke
Rat anococcygeus alpha(1)-adrenoceptors,
GABA(B)
Krebs'
Rat or Rabbit aorta alpha(1)-adrenoceptors,
5HT(2),
neurokinin NK(1),
bradykinin B(1),
angiotensin AT(1),
CGRP(1)
Krebs'
Rat atrium beta(1)-adrenoceptors,
ACh (muscarinic), M(2)
Krebs'
Rat colon Neurokinin NK(2) Krebs'
Rat phrenic
nerve/diaphragm
ACh (nicotinic) Krebs'
Rat portal vein Neurokinin NK(3) Krebs'
Rat uterus beta(2)-adrenoceptors,
histamine H(2),
bradykinin B(2)
De Jalon
Rat vas deferens
(field-stimulated)
alpha(2)-adrenoceptors,
mu-opioid,
prostanoid EP(3)bradykinin B(2),
CGRP(2)
Krebs' (minus Mg(2+))

* - Commonly but not exclusively used
fd smd - (field stimulated)

 

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