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In vitro pharmacology: common isolated tissue preparations
GIF version of table
Preparation |
Receptors commonly studied |
Bathing Solution * |
Frog rectus abdominis |
ACh (nicotinic, muscle-type) |
Frog Ringer |
Guinea-pig ascending colon |
5HT(4) |
Krebs' |
Guinea-pig ileum |
ACh (muscarinic M(3)), histamine H(1) & H(3),
neurokinin NK(1),
bradykinin B(2), 5HT(3),
CCK(A), CCK(B), Angiotensin AT(2) |
Krebs' or Tyrode |
Guinea-pig ileum
(fd smd.) |
mu- and kappa-opioid,
alpha(2)-adrenoceptors |
Krebs' or Tyrode |
Guinea-pig vas deferens |
EP(3) |
Krebs' |
Mouse vas deferens (fd smd.) |
mu- kappa- and delta-opioid,
dopamine D(2) |
Krebs' (minus Mg(2+)) |
Rabbit jejunum |
alpha(2)-adrenoceptors |
Tyrode |
Rabbit heart
Langendorff |
beta(1)-adrenoceptors |
Ringer-Locke |
Rat anococcygeus |
alpha(1)-adrenoceptors,
GABA(B) |
Krebs' |
Rat or Rabbit aorta |
alpha(1)-adrenoceptors,
5HT(2),
neurokinin NK(1),
bradykinin B(1),
angiotensin AT(1),
CGRP(1) |
Krebs' |
Rat atrium |
beta(1)-adrenoceptors,
ACh (muscarinic), M(2) |
Krebs' |
Rat colon |
Neurokinin NK(2) |
Krebs' |
Rat phrenic
nerve/diaphragm |
ACh (nicotinic) |
Krebs' |
Rat portal vein |
Neurokinin NK(3) |
Krebs' |
Rat uterus |
beta(2)-adrenoceptors,
histamine H(2),
bradykinin B(2) |
De Jalon |
Rat vas deferens
(field-stimulated) |
alpha(2)-adrenoceptors,
mu-opioid,
prostanoid EP(3)bradykinin B(2),
CGRP(2) |
Krebs' (minus Mg(2+)) |
* - Commonly but not exclusively used
fd smd - (field stimulated)
Physiological
salt solutions
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