Neurotransmitters and other chemical signalling agents
| 5-HYDROXYTRYPTAMINE (5HT; serotonin) | |||
|---|---|---|---|
| Precursors: | Tryptophan (a) -> 5-hydroxytryptophan (b) -> 5HT |
||
| Synthesising enzymes: | (a) Tryptophan hydroxylase, (b) 5HTP decarboxylase |
||
| Metabolising enzymes: | Monoamine oxidase (MAO) | ||
| Metabolite: | 5HIAA | ||
| Receptor subtypes | Agonists | Antagonists | Second messenger |
| 5HT(1A) | 8-OH-DPAT | Way 100135, SDZ 216-525 |
(-ve) cAMP |
| 5HT(1B) | CP 93129 | Cyanopindolol | (-ve) cAMP |
| 5HT(1C) | now re-classified as 5HT(2C) | ||
| 5HT(1D) | 5CT, sumatriptan | Methiothepin, methysergide |
(-ve) cAMP |
| 5HT(1D-alpha) MB | |||
| 5HT(1DB) MB (human homologue of the rodent 5HT1B receptor) | |||
| 5HT(1E-alpha) MB | (-ve) cAMP | ||
| 5HT(1EB) MB | (-ve) cAMP | ||
| 5HT(1F) MB | (-ve) cAMP | ||
| 5HT(2A) (old 5HT(2)) |
DOI | Ketanserin | PI |
| 5HT(2B) (rat fundus) |
DOI | Ketanserin | PI |
| 5HT(2C) (old 5HT1C) |
mCPP | Mesulergine | PI |
| 5HT(3) | 2-Me-5HT | Ondansetron, granisetron |
(+ve)g(cation) |
| 5HT(4) | 5MeOTrp, cisapride |
GR 113808 | (+ve)cAMP |
| 5HT(5) MB | (binds bufotenine) | ||
NB: (+ve) indicates increase; (-ve) indicates decrease.
Reviews
Peroutka, S. (1992) Neuropharmacol. 31, 609-613.
Zifa, E. and Fillion, G. (1992) Pharmacol. Revs. 44, 401-458.
Harrington, M.A., Zhong, P., Garlow, S.J. and Ciaranello, R.D. (1992) J. Clin.
Psychiatr. 53 (Oct. suppl.) 8-27.
Nitric Oxide
Histamine
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