Neurotransmitters and other chemical signalling agents
| BRADYKININ (BK) | |||
|---|---|---|---|
| Precursors: | Kininogens | ||
| Synthesising enzyme: | Kallikrein | ||
| Metabolising enzyme: | ACE, kininase I (carboxypeptidase-N) | ||
| Metabolites: | Des-Arg9-bradykinin, other fragments | ||
| Receptor subtypes | Agonists | Antagonists | Second messenger |
| B1 | Des-Arg9-BK | Des-Arg9, Leu8-BK Des-Arg10-HOE140 |
? |
| B2 | Hyp9,Tyr(Me)8-BK | NPC567, HOE140, NPC349 |
PI |
NB: (+ve) indicates increase; (-ve) indicates decrease.
Reviews
Farmer, S.G. and Bunch, R.M. (1992) Ann. Rev. Pharmacol. Toxicol. 32,
511-536.
Regoli, D., Rhaleb, N-E., Dion, S. and Drapeau, G. (1990) Trends Pharmacol. Sci.
11, 156-161.
Plevin, R. and Owen, P.J. (1988) Trends Pharmacol. Sci. 9, 387-389.
Cholecystokinin
ATP
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